Validated liquid sterilization

domnick hunter provide a range of sterilising grade filtration products for both aqueous and solvent applications. These offer validated microbial removal efficiency (including mycoplasma) at 0.2 and 0.1 micron ratings. All products are supported by detailed validation documentation.

PROPOR PES - incorporating a high flow, low binding polythethersulphone membrane

TETPOR LIQUID - designed for more aggressive solutions incorporating a high permeability polytetrafluoroethylene (PTFE) membrane

Full Validation Support
Provided by TSG to the latest regulatory requirements, including in-house bacterial challenge validation facilities, coupled with training in the use of domnick hunter integrity test instrumentation.

Absolute pre-filtration

Comprehensive Range
domnick hunter's range of absolute rated pre-filtration products encompasses membrane and multi-media formats. Products are available to match requirements from clarification of process streams through to protection of terminal sterilising filters.

• graded density media for high flow rate and capacity
• wide ranging compatibility with material options from Polypropylene to PTFE
• absolute depth media filter ratings from 0.6 - 100 microns
• membrane based pre-filtration down to 0.04 micron

Comprehensive Support
TSG's knowledge and experience in the optimisation of filter processes can bring significant benefits to the efficiency of downstream processing and manufacturing operations.

Validated gas sterilisation

Class Leading Performance
domnick hunter's TETPOR family of PTFE membrane based gas filters offer outstanding performance in all gas sterilising applications.

• validated for bacterial and bacteriophage removal
• integrity testable using all methods
• high flow format giving exceptionally low differential pressures
• stabilised polymers for multi steam cycle exposure
• selected constructional materials for continuous high temperature operation

Full Validation Support
Provided by TSG to the latest regulatory requirements, including in-house bacterial challenge validation facilities, coupled with training in the use of domnick hunter integrity test instrumentation.

Enhances gas filter performance

Dirt and Oil Free Gases
domnick hunter's OIL-X range and PREPOR GFA gas pre-filters ensure cleanliness of all your compressed gas feeds.

• high capacity bound glass fibre media
• cost-effective, general purpose oil and particulate removal

Enhanced Sterility Assurance
Gas sterilisation filters are protected from excessive contamination using the domnick hunter PEPLYN AIR product range, extending sterilising grade product life-time.

• pharmaceutical grade all polypropylene construction
• graded density media for high capacity
• sterilising grade filter protection
• repeatedly steam sterilisable

Clean/pure steam

Protected Steam Systems
The use of domnick hunter's range of steam filters protects your system from particulate contamination generated through pipework corrosion with chemically aggressive pure steam and enables conformance to current ISPE guidelines.

SINTERED STEAM - corrosion resistant, high strength, 316L sintered stainless steel filters rated to 1µm in steam

HIGH FLOW PLEATED STEAM - 316L stainless steel pleated metal fibre filters enable smaller system sizes or increased flows

HIGH FLOW TETPOR - PTFE membrane filters ensure particulate free steam for critical applications

Maximised fermentation capacity

TURBOSEP™
domnick hunter's unique mechanical separator removes and recycles foam aggregate and aerosol from bio-reactor off-gas giving:

• increased fermenter volume utilisation
• reduced antifoam usage
• improved yields
• protection of sterilising grade off-gas filters
• improved environmental safety
• hygienic design for ease of CIP

The TSG offers installation guidance and advice with on-site, post installation support in the optimisation of your fermentation/cell-culture process.